Police scouring the scene of a house fire on the Sunshine Coast have discovered human remains.

A woman has died in a house fire on the Sunshine Coast.

Firefighters were called to a retirement neighbourhood in Pelican Waters about 5am on Saturday, where a single level home on Archer Court was well alight.

Six fire crews fought the flames, a Queensland Fire and Emergency Service spokeswoman said.

Neighbours say they heard a woman screaming “at the top of her lungs” after they were woken by “an almighty crack”.

A 77-year-old man was taken to hospital to be treated for burns and smoke inhalation, however a woman who lived at the house remained unaccounted for.

On Saturday afternoon, police advised they had found human remains while searching the blackened shell of the house.

“The deceased is yet to be identified,” police said in a brief statement.

One neighbour told ABC radio he ran outside to find a confronting scene.

“I saw Mario, the owner of the house, out the side, with burns all to his hands and arms, and his wife unfortunately didn’t make it out.”

The house was sealed off and will remain a crime scene as police investigate the cause of the fire.

The man was forcibly pulled away from the burning building as he attempted to fight the flames with a garden hose, according to News Corp Australia.

The home was reportedly occupied by an elderly Italian couple who moved to the neighbourhood in 1998.